When transitioning from male to female (MTF), hormone replacement therapy (HRT) typically involves taking estrogen and anti-androgens. The effects of these hormones are varied and can differ from person to person, based on factors like age, dosage, individual body variations, and more. However, there is a general timeline that many individuals experience:

  1. 1-3 Months:
    • Emotional Changes: Many report feeling an overall sense of calm or a reduction in feelings of dysphoria. Mood swings can occur as the body adjusts to new hormone levels.
    • Skin: The skin might start to become softer or drier.
    • Body Fat: Redistribution begins, especially around the hips and chest, but it’s subtle at this stage.
    • Breast Development: Breast buds might form, leading to tenderness or soreness in the chest area.
    • Libido: A decrease in libido is common, as well as changes in erections.
  2. 3-6 Months:
    • Breast Growth: Continued development of breast tissue. This can be accompanied by pain or itching.
    • Facial Changes: Fat redistribution may begin to alter the shape of the face slightly.
    • Muscle Mass: A decrease in muscle mass and strength, particularly in the upper body.
    • Body Hair: A reduction in the growth rate and density of body hair, though facial hair is typically more resistant to change.
    • Scalp Hair: Some report a slowing or stoppage of hair loss, and occasionally some regrowth.
  3. 6 Months – 1 Year:
    • Skin: Continued softening and a more “feminine” appearance.
    • Breast Growth: Continued development, though the pace might slow down.
    • Fat Redistribution: More noticeable changes in the face, hips, buttocks, and thighs.
    • Voice: Hormones don’t typically affect the voice in MTF individuals. Voice training or surgery may be pursued to achieve a more traditionally feminine pitch and resonance.
  4. 1-3 Years:
    • Breast Growth: Most significant growth usually happens within the first couple of years, though development can continue beyond this.
    • Body Hair: Continued reduction and thinning, but again, facial hair typically requires laser removal or electrolysis for significant reduction or removal.
    • Fat Redistribution: Ongoing and becomes more pronounced.
  5. Beyond:
    • Most physical changes stabilize around this point. Some subtle changes might continue, particularly in fat distribution.

Important Notes:

  • The effects of HRT become more pronounced over time, and some effects are permanent while others are reversible. For example, breast growth is permanent, but fat redistribution or skin changes might revert if HRT is stopped.
  • While many effects begin within months of starting HRT, they might take years to fully develop.
  • HRT affects individuals differently based on genetics, age, and other factors. Some might experience significant changes quickly, while others might have a more gradual transition.
  • Regular medical monitoring is essential while on HRT to check hormone levels and ensure no adverse side effects are occurring.

Always consult with a healthcare provider when considering or undergoing HRT to ensure appropriate dosages, monitor side effects, and receive individualized care.