The specific hormone regimen for male-to-female (MTF) hormone therapy varies depending on individual factors such as overall health, age, personal preferences, and the guidance of a healthcare professional. It’s important to consult with a qualified healthcare provider who specializes in transgender healthcare to discuss the best hormone options for your specific situation. They can evaluate your medical history, conduct necessary assessments, and provide personalized recommendations.

Typically, MTF hormone therapy involves the use of estrogen and anti-androgen medications. Estrogen helps develop feminine secondary sex characteristics, while anti-androgens block the effects of testosterone, allowing for the feminizing effects of estrogen to take place more fully.

The most commonly used forms of estrogen for MTF hormone therapy include:

1. Oral Estrogen: This is taken in pill form and is usually the initial form of estrogen prescribed. It’s convenient but can have a higher risk of blood clotting compared to other administration methods.
2. Transdermal Estrogen: These are patches or gels applied to the skin, which deliver estrogen gradually. They can be a safer option for those with an increased risk of blood clotting.
3. Injectable Estrogen: Injections provide a more direct and consistent delivery of estrogen into the body. They are typically administered intramuscularly or subcutaneously and may require less frequent dosing.

Anti-androgens are often prescribed alongside estrogen to suppress the effects of testosterone. Commonly used anti-androgens include:

1. Spironolactone: This medication is commonly prescribed as an anti-androgen due to its ability to block the effects of testosterone. It also has mild diuretic properties.
2. Cyproterone Acetate: This anti-androgen is more commonly used outside of the United States and is known for its potent testosterone-blocking effects.
3. GnRH Agonists: Medications like leuprolide or triptorelin are sometimes used to suppress testosterone production at its source, by reducing the production of luteinizing hormone (LH).

It’s important to note that hormone therapy for MTF transition is highly individualized, and the dosages and medication choices may vary. Regular monitoring of hormone levels, liver function, and other health markers is typically recommended to ensure the therapy is safe and effective.

Always consult with a qualified healthcare professional to discuss the best hormone therapy options for your specific needs, and follow their guidance for dosages, administration methods, and potential risks and benefits.